Cambion

Cambion are the children of a Demons and Humans. The offspring contains a mixture of human soul and demonic abilities.

History
Cambions are the offspring of demons by human mothers. They are also known as katako or the Antichrist. Castiel corrects the idea that the Antichrist is the son of Satan. The Bible, according to Castiel, "gets more wrong than it does right," and the Antichrist is not the son of Lucifer but demon spawn born of humans. This lineage makes them incredibly powerful and with Lucifer on the rise, they become more powerful, so powerful they are capable of "killing the Host of Heaven with one word" according to Castiel. Because of this he is insistent that Jesse Turner - a cambion - must be killed. It is unclear how cambions are conceived; Jesse's mother, Julia Wright, was a virgin when she was used as a demon's host, but no reference was made to the conception. Castiel implies that cambions are hard to create, suggesting that other factors were involved than a choice of host. Cassie was conceived while Dean was a demon.

Physical Appearance
They have various eye and hair color. Some may posses uniquely colored eyes or hair.

Eyes
Cassie eyes turn black when she uses her demonic powers while Jesse's eyes didn't change when he used his powers.

Powers, Skills, and Abilities

 * Reality Warping -  Castiel claimed that, at the peak of the cambion's power, Jesse could destroy the Host of Heaven "with a word".
 * Biokinesis - Cassie can manipulate the bodies of various beings to either harm or disfigure them. She can alter the physiology of most supernatural entities. She can use this power to inflict massive damage to any being, even an Archangel level entity.
 * Conjuration - She conjuried brugers for Sam and Dean when the latter said he was hungry.
 * Conversion/Transformation - She also turned three demons into barbies, with just a thought and back when asked.
 * Terrakinesis - She caused a minor earthquake when she became angry and clenched her fist.
 * Clairvoyance -
 * Voice Mimicry -  She can mimic any person's voice. Shown when she used her father‘s voice to make Robbie and Sandra to leave her alone.
 * Demon Control/Exorcism - Jesse was able to exorcise a demon simply by verbally commanding the demon to leave their host, and was able to immobilize and silence one with a command.
 * Supernatural Concealment - He is hidden from angels, humans, and demons, unless he wants to be found.
 * Telekinesis - He was able to move a seat by simply ordering a demon to sit down.
 * Teleportation - Jesse could teleport anywhere on Earth at a thought.

Weakness

 * Demon-Killing Knife (Possibly) - Castiel attempted to kill Jesse with this blade. The actual effectiveness of the knife, if any, is thoroughly unknown.
 * Lucifer's absence - Jesse's powers were activated and strengthened when Lucifer was present on Earth.